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Organotypic Manuscripts

IQ MPS develops and publishes manuscripts with the purpose of outlining the contemporary pharmaceutical industry perspective and considerations for developing, evaluating, and characterizing MPS models to support drug discovery and development.

Cell Therapies

Candarlioglu, P. L., Delsing, L., Gauthier, L., Lewis, L., Papadopoulos, G., Freag, M., Chan, T. S., Homan, K. A., Fellows, M. D., Pointon, A. (2024) Application of Microphysiological Systems for Nonclinical Evaluation of Cell Therapies. ALTEX Alternatives to animal experimentation

Cell Therapies

Jul 16, 2024

Disease Models

Irrechukwu, O., Yeager, R., David, R. ., Ekert, J., Saravanakumar, A. and Choi, C. K. (2023) Applications of microphysiological systems to disease models in the biopharmaceutical industry: Opportunities and challenges. ALTEX - Alternatives to animal experimentation..

Disease Models

Jul 20, 2023

Immune System

Wang, X., Kopec, A., Collinge, M., David, R., Grant, C., Hardwick, R., Navratil, A., Patel, N., Rowan, W. and Marshall, N. (2022) Application of Immunocompetent Microphysiological Systems in Drug Development: Current Perspective and Recommendations. ALTEX - Alternatives to animal experimentation.

Immune System

Mar 29, 2023

Oligonucleotides

Ramsden, D., Belair, D. G., Agarwal, S., Andersson, P., Humphreys, S., Dalmas, D. A., ... & Cichocki, J. A. (2022) Leveraging microphysiological systems to address challenges encountered during development of oligonucleotide therapeutics. ALTEX-Alternatives to animal experimentation.

Oligonucleotides

Apr 11, 2022

Cardiovascular

Pointon, A., Maher, J., Davis, M., Baker, T. K., Cichocki, J., Ramsden, D., ... & Gintant, G. A. (2021). Cardiovascular Microphysiological Systems (CVMPS) for Safety Studies-A Pharma Perspective. Lab on a Chip.

Cardiovascular

Jan 15, 2021

Gastrointestinal

Peters, M., Choy, A., Pin, C., Leishman, D., Moisan. A., Ewart, L., Guzzie-Peck, P., Sura, R., Keller, D., Scott, C., Kolaja, L. (2019) Developing in vitro Assays to Transform Gastrointestinal Safety Assessment: Potential for Microphysiological Systems. Lab on Chip.

Gastrointestinal

Feb 21, 2020

MPS Organotypic Manuscript 1.0 Introduction

Fabre, K., Berridge, B., Proctor, W., Ralston, S., Will, Y., Baran, SW., Yoder, G., Van Vleet, T. (2019) An Introduction to the Characterization and Use of Microphysiological Systems (MPS) in Pharmaceutical Safety and ADME Applications. Lab on a Chip.

MPS Organotypic Manuscript 1.0 Introduction

Feb 10, 2020

Biologics

Peterson, N., Mahalingaiah, P. K., Fullerton, A., Di Piazza, M. (2019) Application of 3D Cultures and Microphysiological Systems in Biopharmaceutical Research and Development. Lab on a Chip.

Biologics

Jan 22, 2020

Kidney

Philips, J.A., Grandhi, T.S.P., Davis, M., Gautier, J.C., Hariparsad, N., Keller, D., Sura, R., Van Vleet, T. (2019) A Pharmaceutical Industry Perspective on Microphysiological Kidney Systems for Evaluation of New Therapies. Lab on a Chip.

Kidney

Jan 22, 2020

ADME

Fowler, S., Chen, W.L.K., Duigan, D., Gupta, A., Hariparsad, N., Kenny, J., Lai, G., Liras, J., Phillips, J., Gan, J. (2019) Microphysiological Systems for ADME-Related Applications: Current Status and Recommendations for System Development and Characterisation. Lab on Chip.

ADME

Jan 6, 2020

Liver

Baudy, A.R., Otieno, M.A., Hewitt, P., Gan, J., Roth, A., Keller, D., Sura, R., Van Vleet, T.R., Proctor, W.R., (2019) Liver Microphysiological Systems Development Guidelines for Safety Risk Assessment in the Pharmaceutical Industry. Lab on a Chip.

Liver

Nov 20, 2019

Skin

Hardwick, R.N., Betts, C.J., Whritenour, J., Sura, R., Thamsen, M., Kaufman E., Fabre K., (2019) Drug-Induced Skin Toxicity: Gaps in Preclinical Testing Cascade as Opportunities for Complex In Vitro Models and Assay. Lab on a Chip.

Skin

Oct 10, 2019

Lung

Ainslie, G. R., Davis, M., Ewart, L., Lieberman, L. A., Rowlands, D. J., Thorley, A. J., Yoder, G., Ryan, A. M. (2019). Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective. Lab on a Chip.

Lung

Aug 30, 2019

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